She began her soloist career as a mezzo-soprano receiving singing lessons from Lenka Šmídová und since 1997 from Jiří Kotouč.

[1] In 2003, she sang the role of Karolka in Janáček's Jenůfa in a production at the Théâtre du Châtelet in Paris.

[1] In 2011/12, she performed the same role in a co-production of three French opera houses – Rennes, Limoges and Reims.

For the role of Mařenka in Smetana's The Bartered Bride, directed by Ondřej Havelka at the National Theatre in Brno, Vykopalová received a nomination for the Czech Thalia Price in 2006.

[1] She received a nomination for the 2012 Thalia Price 2012 for the role of Míla in Janáček's Destiny at the National Theatre in Brno.