His great-grandfather was Milosav Mišnin Vujisić, famous hero from Donja Morača and commander of the guard of Prince Danilo.

[2] He studied law and literature, and worked as a journalist for Radio Belgrade before getting a small role in 1950 film Čudotvorni mač.

In his long and prolific career he played many different roles, both dramatic and comical, and earned great respect from almost any director with whom he worked.

He is arguably best known for his role in 1972 TV series Kamiondžije (Truck Drivers), where he was paired with comedian Miodrag Petrović Čkalja.

Orson Welles said in interview for former Yugoslav television RTZ that he considered Pavle Vuisić as the best actor in the world.