As a result of joining the academies, Wszołek had to relocate and while at Lechia Gdańsk, he once lived in the dormitory for a month before moving with his mother.

[2] Wszołek made his senior team debut for Polonia Warsaw on 13 November 2010, coming on as a substitute in the second half, in a 3–1 win over Ruch Chorzów.

[23] Despite this, Wszołek stayed at the club and continued to be a regular for the rest of the season, scoring two more league goals against Ruch Chorzow[24] and Podbeskidzie.

As the 2012–13 season was almost came to an end, Wszołek expressed his desire to leave the club when he filed a request the Polish Football Association to terminate his contract at Polonia Warsaw.

[26] It was reported on 6 June 2013 that Wszołek had his contract terminated at the club following an intervention from the Polish Football Association.

[31] After a much confusion, it was finally announced on 9 July 2013 that Wszołek joined Italian Serie A side Sampdoria, signing a four-year contract.

[35] The 2014–15 season saw Wszołek's first team chance even limited at Sampdoria and was given an opportunity to join Bologna in the summer transfer window, but it never happened.

Nevertheless, Wszołek made his first appearance on 5 January 2015, making his first start before coming off in the second half, in a 3–0 loss against Lazio.

[51] Wszołek moved to Championship side Queens Park Rangers on transfer deadline day, 31 August 2016, on a season-long loan deal.

[58] On 31 January 2017, halfway through Wszołek's initial loan QPR exercised an option to sign him permanently for an undisclosed fee.

On 19 September 2019, Wszołek signed with Polish club Legia Warsaw, marking his return to his native country after seven years abroad.

Wszołek entered the starting lineup following the succeeding international break, and scored his first goal for the club in their 7–0 thrashing of Wisła Kraków on 27 October.

On 7 July 2022, Legia announced the permanent signing of Wszołek on a three-year deal until the end of the 2024–25 season, after a successful loan spell.

[65] In his eighth appearance for the national side against Finland on 26 March 2016, Wszołek scored his first goals, in a 5–0 win.

[71] It wasn't until on 10 October 2016 when Wszołek made his first appearance for Poland since being cut from squad for UEFA Euro 2016, where he came on as a substitute for injured Artur Jędrzejczyk, in a 2–1 win over Armenia.