The club have won the league title three times consecutively in 2017, 2018 and 2019.

Peñarol entered a women's team in 2012 and joined the Campeonato Uruguayo Femenino in 2013.

Peñarol ended the hegemony of Colón in 2017 by winning their first league title.

[1] The club repeated this the following two seasons[2] and debuted in Copa Libertadores Femenina in 2018.

[3] In 2020, Peñarol finished runners-up behind their main rivals Nacional.