Pearl River is a census-designated place (CDP) in Neshoba County, Mississippi.

As of the 2020 United States Census, there were 3,822 people, 1,082 households, and 793 families residing in the CDP.

As of the census[4] of 2000, there were 3,156 people, 803 households, and 655 families residing in the CDP.

13.8% of all households were made up of individuals, and 3.0% had someone living alone who was 65 years of age or older.

Pearl River is served by the Neshoba County School District.