Comparison of the shell, radula and morphology suggested a closer phylogenetic relationship to the Pediculariidae than to the Lamellariidae, the Eratoidae/Triviidae, or the Ovulidae.

[2] However, both the validity of the family Pediculariidae, and its proper position within the superfamily Cypraeoidea, remain controversial.

[2] As of 2019, the World Register of Marine Species considers it a subfamily of the family Ovulidae.

[1] According to the taxonomy of Bouchet & Rocroi (2005) the subfamily Pediculariinae was included within the family Ovulidae.

Fehse (2007)[3] raised the subfamily Pediculariinae to the level of family as Pediculariidae, based on morphological research on the radulae, the shell, the soft part morphology and molecular phylogeny research on the 16S ribosomal RNA gene.