Pedro Julio Astacio (born November 28, 1968) is a former Major League Baseball pitcher.

He has played for the Los Angeles Dodgers (1992–1997), Colorado Rockies (1997–2001), Houston Astros (2001), New York Mets (2002–2003), Boston Red Sox (2004), Texas Rangers (2005), the San Diego Padres (2005) and the Washington Nationals (2006).

In 2007, Astacio signed a contract with the Nationals' Triple-A affiliate, the Columbus Clippers, but they released him in May.

Astacio made national news when he tossed a shutout and fanned 10 in his major-league debut.

As of the 2021 season, he stands fifth on the Rockies' career list behind Jorge de la Rosa, Jon Gray, German Marquez and Ubaldo Jimenez.