He is the former manager for the Chicago White Sox of Major League Baseball (MLB).

He also served in various coaching roles for the Kansas City Royals in both their minor league system and at the MLB level.

[2][3] The Minnesota Twins selected Grifol in the sixth round of the 1991 Major League Baseball draft.

[5] Grifol joined the Kansas City Royals organization in 2013 as a minor league coach.

[9] Following a 21-game losing streak, the White Sox fired Grifol on August 8, 2024, after posting a record of 89–190 over two seasons.