In the spring of 1456 he was named Captain-General of the Church and castellan of Sant'Angelo, in the autumn of the same year the Pope made him Governor of Terni, Narni, Todi, Rieti, Orvieto, Spoleto, Foligno, Nocera, Assisi, Amelia, Civita Castellana, and Nepi, and at the beginning of 1457 the governorships of the provinces of Patrimony and Tuscany were added to these.
[1] In the same time his older brother Rodrigo Borgia was created Cardinal Deacon, Commander-in-Chief of the papal troops and Vice-Chancellor of the Holy Roman Church, while another relative Luis Juan del Mila y Borja was also elevated to the cardinalate.
Such rapid promotions of young relatives of the Spanish Pope Callixtus III were criticised by many older cardinals (e.g. Domenico Capranica) and met also with opposition of rather xenophobic Roman populace.
[4] Don Pedro Luis was hated by Romans, like almost all relatives and allies of Callixtus III, called "Catalans" due to their Spanish origin.
[5] On 6 August 1458, the day his uncle the Pope died, he had to flee Rome because an open revolt against "Catalans" had broken out.