He reached his first ATP final as a lucky loser at the 2020 Argentina Open after the withdrawal of top seed Diego Schwartzman in the semifinals but lost to Casper Ruud in the championship match.

[2][3][4] In April 2023, using a qualification wildcard, Sousa qualified into the main draw for his last appearance at an ATP Tour event and his home tournament, 2023 Estoril Open.

He also announced his retirement from professional tennis, the 2023 Lisboa Belém Open Challenger being his final event.

Only ATP Tour main draw and Davis Cup matches are considered.

Sousa debuted for the Portugal Davis Cup team in 2006 and has played 12 matches in 11 ties.