Peenemünde (German pronunciation: [peːnəˈmʏndə], English: "Peene [River] Mouth") is a municipality on the Baltic Sea island of Usedom in the Vorpommern-Greifswald district in Mecklenburg-Vorpommern in north-eastern Germany.

The village with its seaport is located on the westernmost extremity of a long sand-spit, where the Peene empties into the Baltic Sea, in the northwestern part of Usedom Island.

Peenemünde harbour can be reached by ferry boat across the Peene from Kröslin, liners also run along the Baltic coast to Rügen Island.

During the 10th and 11th centuries, Peenemünde was part of the region of Circipania, an area settled by the Circipanes, a West Slavic tribe constituent of the Lutici federation.

The resistance group, later discovered by the Gestapo, was in contact with Allen Dulles, the head of the US secret service OSS in Switzerland.

During Operation Hydra, the research facility was badly hit by the attack by the RAF bomber command on Peenemünde on the night of August 17–18, 1943.

On 1 December 1956 the headquarters of the First Flotilla (de:Erste Flottille (Volksmarine)) of the East German People's Navy was established at Peenemünde.