[6][7] Salimpour first gained national attention for his work in the medical field in the mid-1990s when he led an initiative that fought exclusivity contracts that hospitals had with physicians.

[2] Salimpour's work as a business executive and entrepreneur in the field of medicine including the co-founding of two medical companies and co-ownership of one of San Diego's largest hospitals.

The brothers also founded the physician-owned company Plymouth Health, formed specifically for the purpose of acquiring Alvarado Hospital Medical Center in San Diego, California.

[10] Tenet settled a civil complaint filed against them, which included a $21 million settlement and agreement to either close or sell the hospital.

[4][12][13] Outside of government appointments, he was elected to the board of directors for the American Academy of Pediatrics (California Chapter) and the Los Angeles County Medical Association.

[14] Salimpour is also an educator, working as a professor of clinical pediatrics at the University of California Los Angeles School of Medicine.

[6] His work in the field of medical education led him to write Photographic Atlas of Pediatric Disorders and Diagnosis, a book that he co-authored with his brother Pedram and his father Ralph Salimpour.

He is the co-founder of NexCare Collaborative, a 501c3 organization that helps find affordable health insurance for poor families in the Los Angeles area.

[18] Also known as First 5 LA Connect, the Collaborative provides a call-in line with bilingual staffers who help assist those needing affordable health care or referrals.