Pence is a small unincorporated community in Jordan Township, Warren County, in the U.S. state of Indiana.

In 1903, Pence became the smallest town in the United States to have a central water system.

In the early part of the 20th century, Pence had numerous businesses including a grain elevator, a blacksmith shop, a welding and machine shop, a lumber yard, a coal yard, the Bank of Pence (which closed in the 1920s), a hotel (which also housed the post office for a time), restaurants, a general store, grocery stores, a hardware store, a weekly newspaper, a funeral home, a jewelry store, and various others.

Pence is located less than a mile east of the Indiana-Illinois state line and a quarter mile from Jordan Creek, which flows southwest toward the Vermilion River.

It is on County Road 300 North, which (in Illinois) runs into the town of Rossville about 9 miles to the west.