An elder brother, Captain Robert Booth (died 1742), married in 1725 Lady Susannah Clinton (died 1754), daughter of Francis, 6th Earl of Lincoln, and sister-in-law of Thomas Pelham-Holles, 1st Duke of Newcastle (Prime Minister of Great Britain).

Their only child, Katherine Booth (whose eldest son was Sir Thomas Tyrwhitt Jones) is an ancestor of the 16th and present Baroness Berners.

Elected a Fellow of Magdalene College in 1702, Booth was ordained in 1703 by Dr James Gardiner, Bishop of Lincoln.

He was conferred with the degree of Doctor of Divinity (DD) by Cambridge University in 1728, having been elected a Fellow of the Royal Society (FRS) in 1703.

Dean of Windsor and ex-officio register of the Order of the Garter from 1729 until his death in 1765, Booth was succeeded by former bishop of Exeter, Dr. Frederick Keppel.