The northern terminus is at the entrance of the Wilkes-Barre/Scranton International Airport in Pittston Township just past an interchange with Interstate 81 (I-81).

The route comes to an interchange with I-81 and I-476 (Pennsylvania Turnpike Northeast Extension) before passing through Dupont along a one-way pair.

PA 315 becomes a five-lane road with a center left-turn lane as it passes businesses in Plains Township, running to the northwest of the WOLF-TV studios.

The road runs a short distance to the west of I-81 and passes east of the Mohegan Pennsylvania hotel, casino, and harness racetrack.

The road passes scattered areas of businesses in this area with one northbound lane and two southbound lanes before passing over the Reading Blue Mountain and Northern Railroad's Lehigh Division line and crossing back into Jenkins Township.

In the center of Dupont, southbound PA 315 becomes Main Street, with the two directions of the route joining farther to the north.

PA 315 reaches its northern terminus at the entrance of the Wilkes-Barre/Scranton International Airport, just past a final interchange with I-81 on the border of Avoca and Pittston Township.

[9] The northern terminus of PA 315 was moved to an interchange with I-81 near the Wilkes-Barre/Scranton Airport in 1966, with the former route north of there incorporated into I-81.

[14][15] By 2003, the northern end of PA 315 was shifted back to I-81 near the Wilkes-Barre/Scranton International Airport, replacing SR 2059.