PA 333 continues east and then northeast alongside the railroad line and the river as it runs along the base of forested Blue Mountain, passing through Shawnee and Hawstone.

Here, the route turns south to join PA 75 on Market Street, crossing the Tuscarora Creek into Turbett Township.

[2][3] PA 333 heads through a mix of farmland and woodland before coming into the borough of Thompsontown and passing homes on Mill Street.

PA 333 turns north onto an unnamed four-lane divided highway and reaches an interchange with the U.S. Route 22 (US 22)/US 322 freeway.

At this point, the route crosses back into Delaware Township and becomes a two-lane undivided road again, winding north through forested areas.