PA 760 begins at an interchange with I-80 and I-376 in Shenango Township, heading to the west as a four-lane freeway.

A short distance after beginning, the route reaches the PA 18 interchange, at which point the freeway ends.

The road enters the city of Hermitage and passes a mix of woods and industrial establishments.

The road enters the city of Farrell and turns to the north, continuing to the west of developed neighborhoods and to the east of Norfolk Southern's Wheatland Industrial Track railroad line as it passes more industry, including a large steel mill.

From here, the road continues into downtown Sharon and reaches a roundabout at Connelly Boulevard and an intersection with US 62 Business.