The town is located in the geographic center of Panama along the Inter-American Highway in the wide, flat lowlands of central Coclé.

Nomé was a chief of a local Native American tribe who resisted the Spanish conquistadores and was put to death by colonial officials.

[1] Local legend (unknown origin) has it that Nomé was a chieftain in love with an indigenous woman named Zaratí.

[3] Penonomé is the location of several football stadiums, including the Estadio Virgilio Tejeira, built in 2001.

It was funded by FIFA as a part of the Goal Project to support Panama's national team.