Penrose is a census-designated place (CDP) and post office located in and governed by Fremont County, Colorado, United States.

The CDP is a part of the Cañon City, CO Micropolitan Statistical Area.

[4] Settlers followed the Pike's Peak gold rush (July 1858 and lasted until the creation of the Territory of Colorado on February 28, 1861).

[10] Penrose gained national media attention after a local funeral home, the Return to Nature Funeral Home, was raided by the Fremont County Sheriff's Office in October 2023 due to complaints of a foul smell emanating from the area.

[11] In October 2024, the Funeral Home owners, Jon and Carie Hallford, pleaded guilty in federal court to conspiracy to commit wire fraud for misusing relief money.

[12] They are also facing charges in state court for abusing corpses, money laundering, theft and forgery.

[13] In November 2024, the Hallford's pleaded guilty in state court to multiple counts of abusing corpses.

[18] Many residents commute to work in Colorado Springs, or at the prisons of Florence or Cañon City, or at Holcim in Portland, southeast of town.

Penrose has a single traffic light, a volunteer-run fire station, a trucking company, a gas station, a Veterans of Foreign Wars hall, an elementary school (graduates attend high school in Florence), a doctor's office, a post office, a library, a small grocery store, the Estes Industries model rocket factory, three small restaurants, three medical marijuana dispensaries, and several other businesses.