[3] It provides medical and surgical services, and specializes in the treatment of cardiac conditions and cancer.

Spencer Penrose established the institute to treat people with cancer, like him, with the latest technology.

It became "one of the most famous hospitals in the United States" offering research, diagnosis and treatment, including radiation therapy, of cancer.

[9] The hospital's five-story E Tower building contains a reception area, its critical care and cardiovascular units, administrative and medical offices, gift shop, pharmacy and an employee gym.

Occupants are the Colorado Springs Neurological Associates, the Penrose Hospital Woman's Diagnostic Center, and medical offices.

[12][13] The John Zay House (corner of Tejon and Madison) provides lodging for the families of Penrose Hospital patients who are critically ill, as well as patients receiving treatment at the Penrose Cancer Center and their families.

[17][18] Other amenities include an outpatient pharmacy,[19] women's boutique,[20] gift shop,[21] and wireless internet access throughout the building.

[24] It has a "wellness" room with games, videos and novelties to inspire laughter, which is known to reduce stress hormones, like adrenaline, and increase endorphines which help people feel better.

Complimentary valet service is available at the Main Hospital Entrance from 5:30 am to 8 pm Monday thru Friday and closed on major holidays.

The first floor of the parking garage off of Jackson Street has several spaces allocated for Radiation Therapy patients.

[27] In 2010, Penrose-St. Francis Health Services received 10 five-star ratings in HealthGrades "Hospital Quality in America" report.