Comics new site Bleeding Cool officially covered the first solicitations, which included creators like Matteo Scalera, Jeff Dekal, Joshua Swaby, Marc Aspinall, Vanesa Del Rey, Maria Llovet, and others.

It appeared in spring 1994 and featured work by Adam Hughes, Mark Beachum, Garry Leach, Kevin Nowlan, Mike Harris, Arthur Suydam, Jordan Raskin, Horacio Altuna, and Milo Manara.

Subsequent issues contained work by artists such as Roberto Baldazzini, Richard Corben, Tony Salmons, Bart Sears and Gray Morrow.

From issue #26 to the end of its run, Penthouse Comix was published at standard modern comic-book size, with saddle-stitching, card-stock covers, and glossy interior pages.

[8] After the magazine's successful start, editor-in-chief George Caragonne, who was developing a history of erratic behavior,[9] purged managing editor Horatio Weisfeld during the production of Penthouse Comix #4.

The set included art by Hughes, Julie Bell, Ernie Colón, Glenn Fabry, Frank Frazetta, Mark Texeira, Boris Vallejo, and others.

Overseas editions of Penthouse Comix have been published in England, France, Greece, Italy, Germany, The Netherlands, New Zealand, Australia, South Africa, and Mexico.