Following the foundation of this organisation, Gandhi was similarly appointed chairperson of the Committee for the Purpose and Control and Supervision of Experiments on Animals (CPCSEA) in 1995.

As the founder of the organisation, Gandhi filed litigations in order to bring awareness to the killing of homeless dogs, advocating for the introduction of Animal Birth Control (ABC) programs in various regions of India.

The Animal Birth Control program was developed by the World Health Organization (WHO) in an attempt to provide a solution to the overpopulation of street dogs and the increased dispersal of the rabies virus among such wildlife.

Despite the criticism and challenges the organisation has faced, particularly in relation to the founder Maneka Gandhi, People For Animals continues to run various initiatives alongside instigating changes to their policies.

Since 2004, "over 665 laboratories are registered with the CPCSEA,"[8] ensuring that animal testing on rats, mice, guinea-pigs or rabbits can be only be conducted if approved prior by a panel of scientists in the field or domain being studied.

In association with the Gujarat Society for Prevention of Cruelty to Animals (GSPCA), People For Animals aims to relocate leopards inhabiting public parks in order to "decrease conflicting interests of wildlife conservation and the local people"[9] as opposed to inhumanely removing such wildlife via the means of death.

The Founder of PFA, Maneka Gandhi, has made several statements regarding the future direction of People For Animals, with plans to establish over 600 shelters and provide more ambulance services in every district of India.