His first professional appearance was in a shared concert with his father at the Teatro Lope de Vega, Seville, when Pepe was only seven years old,[1][2] playing a gavotte by Bach and Sevilla by Albéniz.

[3] In 1957 Celedonio Romero left Franco's Spain for the United States with his singer actress wife, Angelita, and his three sons, Celin, Pepe and Angel, settling in the San Diego area.

He has been a special guest at the festivals of Salzburg, Israel, Schleswig-Holstein, Menuhin, Osaka, Granada, Istanbul, Ravinia, Garden State, Hollywood Bowl, Blossom, Wolf Trap, Saratoga and Hong Kong.

His contributions to the field of classical guitar have inspired a number of distinguished composers to write works specifically for him, including Joaquín Rodrigo, Federico Moreno Torroba, Francisco de Madina, Lorenzo Palomo, Michael Zearott, Paul Chihara, Enrique Diemecke, Ernesto Cordero and Celedonio Romero.

[2] On February 11, 2000, King Juan Carlos I of Spain knighted Pepe Romero and his brothers, Celin and Angel, into the Order of Isabella the Catholic.