In the blockbuster comedy The Jerk, he appeared as a lowrider-driving criminal who cons a naive Steve Martin out of money and new tires.

Another notable role was in Scarface, directed by Brian De Palma, as Tony Montana's friend Angel Fernandez.

Serna played the charismatic guru Nanak in Aguruphobia, which he also co-produced.

He has also appeared on stage, including his solo show El Ruco, Chuco, Cholo, Pachuco.

Serna has been honored by the Screen Actors Guild Heritage Achievement Award; the League of United Latin American Citizens, and the Estrella Award for Arts & Culture from the Orange County Hispanic Chamber of Commerce.