In 1962, he began studying at the Experimental Art School in Copenhagen (Danish: Den Eksperimenterende Kunstskole).
During his time there, worked with a variety of mediums, including: painting, graphic arts, 8 millimeter films and performance pieces.
[3] By the time Kirkeby completed a master's degree in arctic geology at the University of Copenhagen in 1964, he was already part of the important experimental art school "eks-skolen."
In 1996, he collaboratively works as a painter for three films with filmmaker Lars von Trier, creating the chapter headings for Breaking the Waves and Antichrist, as well as the visuals for the ouverture to Dancer in the Dark.
[3] In his adult life, Kirkeby lived and worked between Hellerup, Læsø, Frankfurt am Main and Italy.
[5] He announced in 2015 that he had given up all further attempts to resume painting after the accident, but continued to create small etchings.