Oxycodone/paracetamol, sold under the brand name Percocet among others,[2] is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.

[1] In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6 million prescriptions.

[3][4] The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.

[5] In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[6] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.

[7] In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.