He held the seat for almost a year when he left the Commons in 1689 after being called up to House of Lords in his father's barony of Osborne.

He also helped negotiate a proposal of tobacco merchants to ship their products to Russia.

In 1699 he designed the Sixth Rate ship Peregrine Galley, which was launched at Sheerness Dockyard in 1700.

On 25 April 1682, he married Bridget Hyde (the only daughter and heiress of Sir Thomas Hyde, 2nd Baronet) and they had four children: Danby inherited his father's titles in 1712 and upon his own death in 1729, was succeeded in them by his second son, Peregrine.

He was buried in the Osborne family chapel at All Hallows Church, Harthill, South Yorkshire.