They are dimitic or trimitic with smooth, thick-walled basidiospores and cause a white rot in affected wood.

Perenniporia was proposed by American mycologist William Alphonso Murrill in 1943 to contain two species formerly placed in Poria, a genus formerly used to contain all crust-like poroid fungi.

Additionally, P. unita was discovered to be a nomen dubium, which also threatened the validity of the genus Perenniporia.

To remedy this nomenclatural instability, Cony Decock and Joost Stalpers proposed to conserve Perenniporiella with P. medulla-panis as the type.

[3] Although Truncospora has traditionally been considered a synonym of Perenniporia, molecular phylogenetic analysis shows that it is genetically unique and worthy of recognition as a distinct genus.