[1] It was filmed between March 20 and May 2, 1942,[1] with the outdoor action sequences shot primarily at the Iverson Movie Ranch in Chatsworth, California.

Nyoka, the name of the main character in the first film, was instead placed in the title of the sequel, as that name was an original creation of Republic's writers, not of Burroughs.

[1] The serial was re-released on April 2, 1952 under the new title Nyoka and the Tigermen,[6] between the first runs of Radar Men from the Moon and Zombies of the Stratosphere.

[1] Jim Harmon and Donald F. Glut have written that Perils of Nyoka was probably the best jungle-type serial ever made and that it "lavished in increased production values".

[5] Cline noted that Perils of Nyoka stood out in the memories of the original serial audiences, despite the strong competition of 1942.