The firm provides corporate, commercial litigation, intellectual property, and regulatory legal advice to a broad range of clients, including prominent technology companies like Google, Microsoft,[6] Intel, Meta, and Amazon.

Perkins Coie is well-known for advising many of the world’s largest technology companies, including Amazon, Google, and Microsoft as well as large corporations like Boeing, Costco, and Starbucks.

The firm has advised[23] Microsoft on its growing partnership with OpenAI, the research and development company behind ChatGPT [2023], guided[24] YouTube TV on its Sunday Ticket broadcast agreement with the National Football League [2022], and represented[25] Amazon before the International Trade Commission with respect to patent litigation [2023/4].

[citation needed] A team of Perkins lawyers successfully represented Al Franken in his recount and legal battle over the 2008 Senatorial election in Minnesota.

[27] In 2006, Perkins Coie, led by partner Harry Schneider, represented Salim Ahmed Hamdan, the alleged driver and bodyguard of Osama bin Laden.

[28] Perkins Coie worked in the Doe v. Reed case concerning petition signatures in state ballot initiative campaigns, which was argued successfully before the U.S. Supreme Court on April 28, 2010.

[34] As part of its representation of the Clinton campaign and the Democratic National Committee (DNC), Perkins Coie retained the intelligence firm Fusion GPS for opposition research services.

A notable product of that opposition research was the Steele dossier describing alleged attempts by Russia to promote the presidential campaign of Donald Trump.

[35] The FEC conducted an investigation into misreported 2016 payments to Perkins Coie and levied a fine of over $100,000, jointly paid by the DNC and the Clinton campaign.

[36] Perkins Coie was retained to conduct the independent investigation into potential sexual abuse by Richard Strauss during the course of his employment with Ohio State University wrestling program.