[2] The house's architecture is similar in style to many of the I-houses common in eastern Mississippi but is smaller than other more extravagant structures.

[3] The house was owned by a family known as the Dees before being purchased some time around the turn of the century by Burel Wilson (Wilse) and Sarah Elizabeth (Sally) Darnel Perkins.

[2] The Perkins House is significant as an example of a mid-nineteenth century vernacular farmhouse associated with a middle-class family in the rural area of eastern Mississippi during this period.

Shed style porches run the entire length of the front and rear facades and contain cabinet rooms in each corner.

[2] Atop the first floor lies a small attic which was originally inaccessible,[3] but a ship's ladder was installed after 2012 to provide access.

[2] The exterior wall of the enclosed loggia contains 4 four over four double-hung sash windows which break the original symmetry of the facade.

The rear door present at the back of the central passageway when the house was listed on the National Register in 1994 did not include any panels and was likely not original.

The southern room includes a twisted rope pattern as an artificial picture rail and a wainscot along the lower portion of the walls.