Perkinston is an unincorporated community in central Stone County, Mississippi, United States.

[4] The village is named for John C. Perkins (1840–1928), who homesteaded the area after serving in the Confederate Army.

[6] The Perkinston community benefited from the Gulf and Ship Island Railroad, which was constructed through the village in the late 1890s.

Beginning in 1911, Perkinston served mainly as a campus for the Harrison County Agricultural High School, which developed into Mississippi Gulf Coast Community College.

[7] Through time, the village had few commercial establishments, but did have a post office, general store, churches, and a gasoline service station.