The Perrigo-Holmes House is a historic residence located in Boone, Iowa, United States.

Joel C. Perrigo was a Vermont native who worked for several different railroads, including the Chicago and North Western, which probably brought him to Boone.

[2] Perrigo had the two-story, frame high-style Italianate house built around 1871.

The L-shaped structure features paired brackets under the eaves, and the front porch is located in the inside angle.

This article about a property in Boone County, Iowa on the National Register of Historic Places is a stub.