[3] Aguayo was best known as the leader of the Los Perros del Mal stable, which he started in Consejo Mundial de Lucha Libre (CMLL) in mid-2004.

The stable became a significant draw in Mexican professional wrestling, peaking during Aguayo's storyline rivalries with Místico and Héctor Garza.

The four defeated Charly Manson, May Flowers, Nygma and El Picudo to win the Mexican National Atómicos Championship during a show in Jalisco.

[7][8] After Los Junior Atómicos disbanded, Aguayo began teaming regularly with Héctor Garza, engaging in a four-way storyline feud with Heavy Metal and Latin Lover.

[10] Aguayo Jr. and Garza defeated Los Vipers (Abismo Negro and Electroshock) to win the Mexican National Tag Team Championship.

He was initially brought in as a técnico to team with Negro Casas against Los Guerreros del Infierno, but did not receive the expected positive reactions from the crowd, and CMLL decided to turn him heel by having him win a tournament for a shot at Atlantis' Michinoku Pro Wrestling Tohoku Junior Heavyweight Championship.

The title challenge was unsuccessful, but Aguayo was quickly put into a program with Los Capos with the story being he was getting revenge on Universo 2000 for ending his father's career.

Due to El Hijo del Santo's short tour with CMLL, the feud was rushed towards an indecisive singles match.

After that match, Santo focused more on his program with Averno and Los Guerreros del Infierno and Aguayo Jr. set his sights on Casas (to whom he lost), and the feud cooled down from there.

After the match, La Familia de Tijuana (Halloween, Damián 666), and Aguayo Jr. decided to start a new faction, Los Perros del Mal ("The Bad Dogs").

The group took on many rivals, including Negro Casas, Felino, Heavy Metal (who had just jumped from AAA), Máscara Mágica, Universo 2000 and Aguayo's new focus, the rising star Místico, who had defeated him in a main event singles match.

Los Perros del Mal faced off against their rivals in the 2005 "Cage of Death" match, in which Damián 666 took the hair of Máscara Mágica.

On May 5, 2006, Aguayo Jr. was defeated by Rayo de Jalisco Jr. and El Canek in a three-way match for the IWRG Intercontinental Heavyweight Championship in Nezahualcoyotl.

On June 6, 2010, at Triplemanía XVIII, Aguayo returned to AAA to lead Perros del Mal in an invasion of the promotion.

[15][16] On August 14 at Verano de Escandalo El Hijo del Perro Aguayo wrestled his first major match for AAA since his return, when he, L.A. Park and Damián 666 defeated El Mesías, Cibernético and La Parka in a six-man tag team match, when Perro pinned Mesías.

[19] However, he made a surprise appearance on December 5, 2010 during the main event of Guerra de Titanes, helping Damián 666, Halloween and X-Fly hand Los Psycho Circus their first-ever loss in a steel cage weapons match.

[28] Aguayo Jr. was set to wrestle as part of Los Perros del Mal at Triplemanía XIX, facing Los Psycho Circus to determine the first-ever AAA World Trios Champions, but was forced to pull out of the event due to an adverse reaction to the medication given to him as part of his tumor treatment.

[31] Aguayo Jr. returned to pay-per-view on October 9, 2011 at Héroes Inmortales, unsuccessfully challenging Dr. Wagner Jr. for the AAA Latin American Championship in a bullterrier match.

[33][34] On December 16, 2011 at Guerra de Titanes, Aguayo and Evans continued their rivalry in a six-man tag team match, during which they busted each other open.

[37] Afterwards, Aguayo Jr. started a year-long rivalry with Cibernético, which culminated in a lucha de apuesta in the main event of Triplemanía XXI on June 16, 2013.

[43] However, on December 8 at Guerra de Titanes, Aguayo Jr. turned on Cibernético, rejoined Daga and Psicosis and brought Los Perros del Mal back under the umbrella of the reformed La Sociedad.

[45] Later that night in the main event, Aguayo Jr. defeated Cibernético, Dr. Wagner Jr. and Myzteziz, in a four-way elimination match to win Copa Triplemanía XXII.

[61] An alternative angle uploaded by an audience member appears to show Aguayo moving his left leg after the initial impact.

[66] Many promotions, including AAA, CMLL, The Crash, Lucha Underground and World Wrestling League (WWL), paid tribute to Aguayo Jr. following his death.