Perseus and Andromeda is a 1622 painting in the Hermitage Museum by the Flemish artist Peter Paul Rubens of the ancient Greek myth of Perseus and Andromeda after the former's defeat of the Gorgon.

The composition is similar to that of an earlier painting by Rubens, Perseus frees Andromeda (now Gemäldegalerie, Berlin).

Perseus, in the centre of the painting, is surrounded by three putti, one holding the shield with Gorgon's reflection, one wearing the hero's helmet, while the third holds the winged horse Tobiano Pegasus.

Above, Victory, the goddess of glory, is depicted in the act of placing a crown on the hero's head.

In the summer of 1769 the painting was acquired by the Russian Hermitage Museum from the collections of Heinrich von Brühl.