The Persian–Uzbek Wars were a series of conflicts between the Shaybanids and Safavid Empire of Persia fought between 1502 and 1510.

In 1502, shortly after Muhammad Shaybani defeated an invasion by the Ferghanan ruler Babur, Persian emperor Ismail I conquered the rest of Iran.

Shaybani and his horsemen began to raid the Timurid Empire, which was a great superpower founded by the ruthless Timur in the late 14th century.

Badi al Zaman appealed to the shah of Persia for help, and Ismail went to war with the Shaybanids.

At the Battle of Marv, the allied army beat off the Shaybanids, and Shaybani was killed trying to flee.