The British parliamentary constituency was created in 1708 following the Acts of Union, 1707 and replaced the former Parliament of Scotland shire constituency of Perthshire.
The Scottish Reform Act 1832 transferred from Perthshire to Clackmannanshire and Kinross-shire the parishes of Tulliallan, Culross and Muckhart and the Perthshire portions of the parishes of Logie and Fossaway.
The constituency elected one Member of Parliament (MP) by the first past the post system until the seat was abolished in 1885.
Campbell succeeded to the peerage, becoming 2nd Marquess of Breadalbane and causing a by-election.
Murray succeeded to the peerage, becoming 4th Earl of Mansfield and causing a by-election.