By the first half of the 1st millennium BCE, the Petén and Mirador Basin of this region were already well-established with a number of monumental sites and cities of the Maya civilization.
Mesoamerican agriculture was very extensive, and there is some evidence suggesting that the land was depleted by unsustainable overfarming, resulting in a famine which was an important factor in the collapse of the Classic Maya states of this area.
Hernán Cortés led the first expedition to pass through the Petén Basin, in 1524 to 1525, and reported that the region mostly had small hamlets separated by thick forest, with Tayasal being the only sizable inhabited city they observed.
The Spanish town of Flores was established atop the site of Tayasal, but this remained an isolated backwater through the colonial Viceroyalty of New Spain era and after Mexican independence.
When Guatemalan President Rafael Carrera sent a small force to Flores to claim the region for Guatemala in the 1840s, the governments of Mexico and the state of Yucatán decided the Petén Basin area was not worth the trouble of contesting.