He has played lead roles in multiple television series, portraying Casey McCall on Sports Night (1998–2000), Nate Fisher on Six Feet Under (2001–2005), Nick George on Dirty Sexy Money (2007–2009), Adam Braverman on Parenthood (2010–2015), Benjamin Jones on The Catch (2016–2017), and Bobby Nash on Fox/ABC's 9-1-1 (2018–present).

[5] As a teenager, Krause was active in track and field and gymnastics[1] and attended Alexander Ramsey High School in Roseville, Minnesota.

[5] He graduated from high school in 1983 and was a pre-medical student at Gustavus Adolphus College in St. Peter until he discovered acting in his junior year and changed his final major to English Literature.

[6][7] In college, he performed in plays such as Paul Sills' Story Theatre, Caryl Churchill's Cloud 9, and Harold Pinter's The Dumb Waiter, which all led to his full commitment to acting.

[5][9] While in New York City, he worked as a bartender at Broadway's Palace Theatre with Aaron Sorkin, who later created and executive produced Sports Night, which starred Krause.

[15] In December 2006, he played the lead role, Detective Joe Miller, in the Sci Fi Channel miniseries The Lost Room.

[16] From 2007 to 2009, Krause portrayed young lawyer Nick George in ABC's drama Dirty Sexy Money alongside veteran actor Donald Sutherland.