During his U Sports career, Nicastro started at 20 games for the Dinos from 2017 to 2019, and won the Vanier Cup in 2019.

[1] The Toronto Argonauts selected Nicastro with the seventh overall pick in the 2021 CFL Draft.

[7][8] He also missed the entire 2023 season due to this injury and the subsequent surgery, and was on the injured list when the Argonauts defeated the Winnipeg Blue Bombers in the 109th Grey Cup game.

[8] After returning healthy in 2023, Nicastro played and started in 17 regular season games.

[9] He also played and started in all three post-season games, including the 111th Grey Cup where the Argonauts defeated the Winnipeg Blue Bombers 41–24.