[4] On 6 July 2021, De Vries was shot in the head after leaving the television studio of RTL Boulevard in Amsterdam where he had appeared as a guest.

[9] He investigated the murder of Christel Ambrosius,[10] and revealed that Mabel Wisse Smit knew the drug lord Klaas Bruinsma better than she had previously admitted, before she married Prince Friso, a brother to the king.

He attended proceedings and sometimes visited the hotels in France where the kidnappers Cor van Hout and Willem Holleeder were being held under arrest.

[13] The Netherlands is one of the few countries in the world to have a statute of limitations on murder, which stands at 18 years after the offense is committed, which gave De Vries only a short period of time to expose the killer.

[14] On 13 September 2006, De Vries was arrested in Oisterwijk and detained for several hours in Tilburg when he tried to confront a police officer with allegations about questionable actions concerning the inheritances of elderly women.

In what has been De Vries' longest show to date, he spent two weeks in Texas speaking with former CIA and FBI agents and the ex-girlfriend of Lee Harvey Oswald.

[18] In November 2006, a program by De Vries was broadcast in which he accused Joran van der Sloot, one of the prime suspects in the disappearance of Natalee Holloway in Aruba.

[citation needed] On 11 January 2008, Van der Sloot threw a glass of red wine in De Vries' face right after a live broadcast of the Dutch talk show Pauw & Witteman on which De Vries and Van der Sloot (with his parents) had been guests.

During the tense but peaceful conversation during the broadcast, De Vries had on several accounts challenged Van der Sloot's integrity.

He shared his findings with the police, stating that he would publicly show this new-found evidence in a special episode of his television program.

[21] On 3 February 2008, the undercover video aired on Dutch television showing Van der Sloot purportedly smoking marijuana and admitting to being present during Holloway's death.

[26] On 22 September 2008, in New York, De Vries accepted an International Emmy Award in Current Affairs for his coverage while accompanied by Natalee's mother Beth Holloway.

[27] In November 2008, De Vries aired undercover footage of Van der Sloot making preparations for the apparent sex trafficking of Thai women in Bangkok.

[29] Peruvian Minister of Justice Aurelio Pastor said that Thailand is pursuing criminal charges against Van der Sloot.

According to The National Enquirer, he is being investigated for his involvement in the disappearance of young women he may have recruited for a Thai sex slave gang while posing as a production consultant for a modeling agency that would send them to Europe.

On 6 September Perth magistrate Giuseppe Cicchini rejected an application by Ross for a restraining order against De Vries, who had by then left the country.

[37] According to Van der Sloot's attorney Maximo Alonso Altez Navarro, his client was taken to meet them "practically by force.

"[38] Altez Navarro stated that the meeting with Holloway took "less than one minute," with Van der Sloot saying that he could not speak to her without his lawyer present and handing her his business card.

[42] He spent a few days in Aruba working with Holloway on a documentary about her missing daughter to be run on Dutch television, with the cooperation of prosecutors who had been investigating Van der Sloot.

[47] On 6 July 2021, after leaving the television studio of RTL Boulevard in Amsterdam where he had appeared as a guest, five bullets were fired at him at the Lange Leidsedwarsstraat.