After earning his undergraduate degree, Swire studied at the Université Libre de Bruxelles on a Rotary International Ambassadorial Scholarship.

The final text of the rule was announced by President Bill Clinton and the Secretary of Health and Human Services, Donna Shalala on December 20, 2000.

During his time in the Clinton administration, Swire also chaired a 15-agency White House Working Group on updating wiretap law for the Internet age.

[6] In early 2001, Swire resumed his position at Ohio State, and became director in 2002 of the Washington D.C. Summer Program for the Moritz College of Law.

Swire has researched many elements of technology law, including privacy, data brokering,[7][8] electronic surveillance,[9] and computer security.

[12] In Fall 2013, Swire accepted the Nancy J. and Lawrence P. Huang Professor in the Scheller College of Business at the Georgia Institute of Technology.

[13] In January 2015, law firm Alston & Bird hired Swire as senior counsel in its privacy & data security practice.

[14] In Fall 2017, Swire accepted the Elizabeth & Tommy Holder Chair in the Scheller College of Business at the Georgia Institute of Technology.