In 1858, within the context of talks about the unification of the Romanian Principalities, the printing house accepted to publish the secret correspondence of Prince Nicolae Vogoride, without the accord of the censors.

By the end of the year, Vasile Boerescu - a supporter of the union of the Romanian Principalities and future Foreign Minister - offered him the manager position of a modern typography that owned the first mechanical printing press in Bucharest and published the Naționalul newspaper.

The abdication in 1866 of the first ruler of the United Principalities of Moldavia and Wallachia, Alexandru Ioan Cuza, is recorded with sadness there.

Invited by the Interior Minister Ion Ghica, Ispirescu became the head of the State Printing House in 1866.

Ispirescu left Bucharest for the first time in his life in 1880 for a short trip to Roșiorii de Vede, a small town 74.5 miles away.

In 1879 he published Tales of the Wise Old Man - a retelling in an accessible language for children of universal myths and fragments of Greek mythology - with a preface by Alexandru Odobescu.