The Pfeifer Brothers Department Store is a historic commercial building at 522-24 South Main Street in downtown Little Rock, Arkansas.

The ground floor is lined with commercial plate glass display windows, separated by brick pilasters capped with capitals made of terra cotta.

Above the third-floor windows on the Main Street facade there are round-arch elements with small round windows above, while the Sixth Street facade has corbelled brick elements in the same area.

Built in 1899 by the Lasker Brothers to a design by Charles L. Thompson, it was for many years home to the Pfeifer Brothers store, one of the city's leading department stores.

This article about a property in Little Rock, Arkansas on the National Register of Historic Places is a stub.