Phanat Nikhom (Thai: พนัสนิคม, pronounced [pʰā.nát ní(ʔ).kʰōm]) is a district (amphoe) in the northern part of Chonburi province, eastern Thailand.

Phanat Nikhom is an ancient city dating back to Dvaravati period, called Mueang Phra Rot.

In the Rattanakosin era, King Nangklao, Rama III established city, called Mueang Phanat Nikhom in 1828.

In Mon Nang sub-district, there is a shrine to the Twelve Sisters with the rock they used as pillow when they wandered in the wilderness, as well as a Carissa carandas tree related to the legend.

[1] Neighboring districts are (from east clockwise), Ko Chan, Bo Thong, Ban Bueng, Phan Thong of Chonburi Province, Ban Pho and Plaeng Yao of Chachoengsao province).