[6] Di Giuseppe immediately made an impact on the Wolverine's lineup while playing alongside Chris Brown and A.J.

[10] By the end of November, Di Giuseppe led the team with seven goals over 16 games and was one of two NCAA freshman named to the NHL Central Scouting Bureau's preliminary "Ones to Watch" list.

His former linemate Chris Brown had left Michigan after signing an entry-level deal with the Phoenix Coyotes organization.

[16] However, Di Giuseppe struggled to match his freshman production level and gained new linemates in Boo Nieves and Kevin Lynch in February.

The trio immediately developed chemistry together and Di Giuseppe quickly tied Nieves for the team lead in assists with 14.

[6] After the team maintained a 6–1–1 record, Di Giuseppe gained new linemates in Andrew Copp and Tyler Motte.

[24] Having played 115 games with the Wolverines, Di Giuseppe opted to forgo his final year of eligibility, signing a three-year, entry-level contract with the Hurricanes on March 26, 2014.

[25] He was signed to an amateur try-out contract by the Hurricanes' American Hockey League (AHL) affiliate, the Charlotte Checkers, recording one assist in three games to conclude 2013–14 regular season.

On July 18, 2019, as a free agent, Di Giuseppe signed a one-year, two-way contract with the New York Rangers.

[30] By December 2019, Di Giuseppe led the Hartford Wolf Pack with six goals and seven assists for 13 points through 25 games.

Prior to the start of the 2020–21 season, Di Giuseppe signed a contract extension to remain with the Rangers on October 13.

[37] Di Giuseppe was called up again later in February to assist their depleted lineup on their Eastern North America road trip.

[38] Ahead of the 2022–23 season, head coach Bruce Boudreau announced that Di Giuseppe had suffered a lower-body injury and was expected to need two to four weeks to recover.