He played two seasons in Major League Baseball (MLB) for the Toronto Blue Jays and Baltimore Orioles.

[1] Huffman was traded along with Willie Horton from the Athletics to the Toronto Blue Jays for Rico Carty on August 15, 1978, and transferred to the Syracuse Chiefs.

On August 27, 1979, Huffman pitched what easily was his best game in his major-league career, tossing a one-hitter against the Oakland Athletics in Toronto.

Huffman retired the first 11 hitters, faced only 30 batters in total, and gave up the lone hit to Jim Essian in the sixth inning.

"[4] In 1980, Huffman was set to start the season with Toronto, but was optioned to the team's AAA farm club in Syracuse after manager Bobby Mattick chose to go with a four-man rotation.

On July 10, 1985, Huffman was called up to the majors to fill the roster spot vacated by injured reliever Nate Snell.

[8] Huffman only appeared in two games—one on July 13, 1985, against the Chicago White Sox (in which he gave up four earned runs in 1⁄3 of an inning pitched)[9]—in his first stint with Baltimore that year before being sent back to the minors.

"[12] After his release from Rochester, Huffman joined the Minnesota Twins' Portland Beavers AAA farm club for the balance of 1987, posting a 1–2 record with a 9.37 earned run average in nine games.

By 2002, Huffman was living in Rochester, New York and was the supervisor for a welding supply company that distributes high-pressured liquid oxygen, nitrogen, carbon dioxide and flammable gas.