It was designed by Georgina Pope Yeatman, who was one of only four women to be licensed as architects by the Commonwealth of Pennsylvania during the early part of her career.

[1] A three-story, five-bay, U-shaped brown brick building, which was designed in the Art Deco style by Georgina Pope Yeatman[4] of the Bissell & Sinkler architecture firm, the Philadelphia School of Occupational Therapy was built in 1930 as a two-story building.

[5] The front facade features sculptural iron panels, sandstone carvings, and two-story brick pilasters with decorative caps.

The Philadelphia School of Occupational Therapy occupied the building into the late-1950s, after which it housed medical offices associated with the University of Pennsylvania.

Notable alumni of the school included Kamala Nimbkar and Muriel Zimmerman.