In the 2000s, with musicians including the Radiohead guitarist Ed O'Brien, Selway toured and recorded with the 7 Worlds Collide project.

[9][10] With their fourth album, Kid A (2000), Radiohead began integrating drum machines and other electronic percussion into their music.

[13] Describing their collaboration during Radiohead's 2012 King of Limbs tour, Selway said: "One [of us] played in the traditional way, the other almost mimicked a drum machine.

"[17] In 2008, Mojo wrote that Selway and Colin Greenwood were "surely the most inventive rhythm section working close to the rock mainstream".

[21] It features Selway on acoustic guitar and vocals, and performances from the Wilco members Glenn Kotche and Pat Sansone and the 7 Worlds Collide artists Lisa Germano and Sebastian Steinberg.

[23] On 25 July, he released an EP, Running Blind, comprising songs left off Familial rerecorded with a full band.

[24] Selway's second solo album, Weatherhouse, was released on 6 October 2014, featuring more ambitious instrumentation and electronic elements.

[28] In 2014, Selway and O'Brien signed an open letter protesting a ban on guitars in British prisons and stating that music was important for rehabilitation.

[36] For the 2005 film Harry Potter and the Goblet of Fire, Selway appeared as part of the wizard rock band Weird Sisters with the Radiohead guitarist Jonny Greenwood, Jarvis Cocker and Steve Mackey of Pulp, Steven Claydon of Add N to (X), and Jason Buckle of All Seeing I.

[37] With O'Brien, Selway contributed to the 2001 live album by 7 Worlds Collide, a band formed by the New Zealand songwriter Neil Finn.

[40] The Pitchfork critic Stephen M. Deusner was impressed by Selway's vocals, praising his "subtle melodic hooks and arcing, textured voice".

[39] Selway appears on "Rest on the Rock" and "Out of Light" on the album Before the Ruin by Roddy Woomble, Kris Drever, and John McCusker.

According to the songwriter, Hazel Wilde, Selway helped them create a "whole other version" of the album and restored their confidence in the songs.