Wheeler was also a member of the Oakland Raiders, Miami Dolphins, San Francisco 49ers, Atlanta Falcons, and Arizona Cardinals.

In the 2005 season, Wheeler recorded 65 total tackles, 11.5 tackles-for-loss, 4.5 sacks, four interceptions, eight passes defended, and one forced fumble.

[3] Wheeler was selected by the Indianapolis Colts in the third round (93rd pick) of the 2008 NFL draft.

[14] In the 2016 season, Wheeler and the Falcons reached Super Bowl LI, where they faced the New England Patriots on February 5, 2017.

In the Super Bowl, he had one total tackle as the Falcons fell in a 34–28 overtime defeat.